Selection bias is increasingly acknowledged as a limitation of Mendelian randomization (MR). However, few methods exist to assess this issue. We focus on two plausible causal structures relevant to MR ...

Genome-wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for ...

Intelligence and education are predictive of better physical and mental health, socioeconomic position (SEP), and longevity. However, these associations are insufficient to prove that intelligence and ...

MicroRNAs (miRNAs) have pivotal roles in gene regulation. Circulating miRNAs have been developed as novel candidate non-invasive biomarkers for diagnosis, prognosis, and treatment response for ...

What is post-randomization bias? Marriage is a potentially wonderful union between two individuals who are in love. Interestingly, almost 50 percent of all marriages in the United States will end in ...

While randomization is required by regulatory bodies, it is up to the sponsor on how to conduct it. Developing a clinical trial’s effective monitoring plan can be overwhelming. The FDA acknowledges ...