Researchers in Nikolaus Rajewsky's lab at Max Delbrück Center combined high-resolution, single-cell spatial technologies to map a tumor's cellular neighborhoods in 3D and identify potential targets ...

The field of spatial transcriptomics utilizes technologies that map gene expression data to specific cellular locations within tissues. While traditional RNA sequencing methods generate quantitative ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche ...

This illustration summarizes how integrated spatial transcriptomics, single-cell transcriptomics, single-cell epigenomics, and spatial epigenomics enable multi-dimensional profiling of the tumor ...

Single-cell RNA sequencing has transformed biology by showing which genes are active in individual cells. However, this approach requires cells to be removed from their natural environment, erasing ...

Spatial biology is reshaping how researchers study cancer by revealing the architecture and complexity of tumors in extraordinary detail. Through techniques that combine protein- and gene-level ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

A core challenge in biology is understanding how processes in the body, such as cellular development and regeneration, unfold ...

RNA sequencing (RNA-Seq): A high-throughput transcriptomics method that identifies and quantifies RNA molecules in a biological sample by converting them into sequencing libraries, or in some ...